of, pertaining to, or located in an acinus.
each year, about 200 to 400 americans develop acinar cell carcinoma, a rare form of pancreatic cancer that has no effective standard of care. john a. copland iii, ph.d., discusses a study involving researchers on mayo clinic's campuses in jacksonville, florida, and rochester, minnesota, who found that the chemotherapy drug oxaliplatin is effective in stopping the growth of this cancer. mayoclinic.org
alk rearrangements are found in about 3%-7% of lung cancers. alk rearrangements are more likely to occur in certain tumors that form a glandular appearance when viewed microscopically (signet ring or acinar adenocarcinomas), in light smokers (<10 pack-years) or never-smokers, and in younger people. diagnosis of the alk rearrangement or the presence of other driver mutations is done on laboratory studies of tumor tissue. medicinenet.com
causative mechanisms are not fully understood. the currently prevailing "free fatty acids" theory suggests that at the onset of pancreatitis, high concentrations of toxic free fatty acids generated from the breakdown of triglycerides by pancreatic lipase injure the endothelial lining of small pancreatic blood vessels and acinar cells of the pancreas. the resulting acidic, ischemic environment triggers further free fatty acid toxicity and hastens a systemic inflammatory response.4,7 medpagetoday.com
gallstones cause about 40% of cases of acute pancreatitis. the precise mechanism of gallstone pancreatitis is unknown but likely involves increased pressure in the pancreatic duct caused by obstruction at the ampulla secondary to a stone or edema caused by the passage of a stone. ductal hypertension results in aberrant activation of digestive enzymes from acinar cells. the toxic effects of bile acid itself on acinar cells might also be a mechanism. gallstone pancreatitis is rare in pregnancy and occurs most commonly in the 3rd trimester. merckmanuals.com