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dopa Definitions

noun

the amino acid dihydroxyphenylalanine that is generated in the liver from tyrosine and then converted into dopamine in the brain.

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  • i was getting ready to try the 5-hpt with tyrosine and stumbled on this website. it is research done by the u of minnesota, if memory serves me (http://www.neuroassist.com/5-htp-tyrosine-dopa-treatment-protocols.htm, and bottom line, their research and treatment protocol utilizing 6-htp, tyrosine, cysteine, and dopa have been phenomenally successful. they list at this website a beginning dosage and if that does not work, they recommend urinalysis to see what more or less should be added to their protocol dosages. they then go to the second stage and third. most people respond to the initial dosage. remarkable research and genuine hope for those who have suffered from depression all their lives. everydayhealth.com

  • when drugs such as levodopa (l-dopa) are taken orally, many of the worst symptoms are lessened. new drugs such as pramipexole (mirapex) and ropinirole (requip) can delay the need for levodopa. apomorphine (apokyn) is used treat episodes of reduced mobility in patients with advanced parkinson's that responds less effectively to levodopa. future approaches to treatment include a focus on early detection and slowing progression of the disease. encouraging results have been reported from surgical insertion of a pacemakerlike device deep in the brain to suppress uncontrolled movements, but surgical transplantation of fetal dopamine-producing cells failed to show significant benefits in a controlled study. traditional surgery can alleviate some tremors, and physical therapy may help mobility. factmonster.com

  • when drugs such as levodopa (l-dopa) are taken orally, many of the worst symptoms are lessened. new drugs such as pramipexole (mirapex) and ropinirole (requip) can delay the need for levodopa. apomorphine (apokyn) is used treat episodes of reduced mobility in patients with advanced parkinson's that responds less effectively to levodopa. future approaches to treatment include a focus on early detection and slowing progression of the disease. encouraging results have been reported from surgical insertion of a pacemakerlike device deep in the brain to suppress uncontrolled movements, but surgical transplantation of fetal dopamine-producing cells failed to show significant benefits in a controlled study. traditional surgery can alleviate some tremors, and physical therapy may help mobility. infoplease.com

  • for most brain tumors, radiation treatment is guided by a magnetic resonance imaging (mri) scan. in this study, information from a special scan, called a positron emission tomography/ computed tomography (pet/ct) scan using an amino acid called fluorine-18-l-dihydroxyphenylalanine (18f-dopa) will also be used to image the tumor and guide your radiation oncologist in determining locations to treat with radiation. this type of scan has shown promise in being able to better distinguish tumor from normal brain tissue and may help to more accurately plan radiation treatment. this type of scan can also assist the radiation oncologist in identifying the most aggressive regions of the tumor. the goal of this study is to use the 18f-dopa pet/ct scan to help determine where the disease is that needs to be treated with radiation, in order to improve the effectiveness of radiation in this tumor. mayoclinic.org

  • diseases of the heart and blood vessels (cardiovascular disease): due to the levodopa (l-dopa) in cowhage, it should be avoided or used cautiously in people with cardiovascular disease. l-dopa can frequently cause low blood pressure on standing (orthostatic hypotension), dizziness, and fainting. much less frequently, l-dopa can also cause pounding or irregular heartbeat. medicinenet.com

  • at least four mutations in the spr gene have been found to cause dopa-responsive dystonia. this condition is characterized by a pattern of involuntary muscle contractions (dystonia), tremors, and other uncontrolled movements and usually responds to treatment with a medication called l-dopa. dopa-responsive dystonia can be caused by mutations in one copy or both copies of the spr gene in each cell. these mutations lead to the production of a sepiapterin reductase enzyme with reduced or absent function. in most parts of the body, there are alternate pathways that do not use sepiapterin reductase for the production of tetrahydrobiopterin, but these processes do not occur in the brain. therefore, people with sepiapterin reductase deficiency have a lack of tetrahydrobiopterin in the brain, which affects the production of dopamine and serotonin. the lack of these two neurotransmitters causes the movement problems and other characteristic features of dopa-responsive dystonia. medlineplus.gov

  • rumana chowdhury, md, and colleagues administered l-dopa or placebo to 32 participants mean age 70 and compared their performance on the two-armed bandit with a 22 young adults, mean age 25. the older participants also had baseline fmri studies, which revealed abnormal signaling in the nucleus accumbens in some of the older adults. medpagetoday.com

  • dopa-responsive dystonia: this rare form of dystonia is hereditary. symptoms of dopa-responsive dystonia usually begin during childhood. typically, one leg is affected first. as a result, children tend to walk on tiptoes. symptoms worsen at night. walking becomes progressively more difficult, and both arms and legs are affected. however, some children have only mild symptoms, such as muscle cramps after exercise. sometimes symptoms appear later in life and resemble those of parkinson disease. movements may be slow, balance may be difficult to maintain, and a tremor may occur in the hands during rest. symptoms lessen dramatically when people are given low doses of levodopa. if levodopa relieves the symptoms, the diagnosis is confirmed. merckmanuals.com