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  • �1�'����x�����v��[email protected]���]��^gs=q��p��fb$(w��@�&c����a���&�}�p�f�������$��]3ir��, |���@t7��y��{�e��2�������*�����^��a�������l�fz��x�u-�0��r�q*��:��n�y�v�4��zu�go�aqe����"����s8����m��i�rz���f��yn'r| ����e������������y���m;z���;��k�_�)$����:������j�������������%#�za�w���=�������y�y�f���z8qe�n�7/����zjoef���l��'���f=��f����b��t�a��?~']��;zd�����br,�g�& �o��6��[*b����x�8zymi�$�'m�w�^��;����0� �@ �� � ��a�)lf(����c-�v������4����t���[email protected]������e:�����v����br�a���m��� �%bx������a���&����x���s�v�����vn�f�l]�~�z�����f��p6�y���� a�>(��$�/����c1t����00�8;�b�)w���������"�{��~�f]j�kmg&� ���.�c hc�*!.���li\�&�l��;���}f������$]��%��*mx����b��a����;f������b�pd`zr�6��4tkd�e����o��^cz[��k�lu��0�j��>&8w'�8���0`�f��%f�t��4��7p�|sk}������o�a�_{������hw�5�s��x�p����|��-,]��������7so�g4��c�)1-f��g[!4k���@z1�|�w��n�wie�c6���.� ~�����2����mi�;���c0�����^�~*���i0��,ew.`c��c��aj��ht)t�n�������d������ �����u��e���#�^z��-����)���!�h���ici����n`j�>s��������w6|m������6jb��|���ma�te�l������$k,����=g��a�z3�� / m�]�$~��{o�������_�e��l�5���^ ��~h�a����#px�j���5�����&~s5q+���&2p��,��3�n����alr� �>�������j��n/>h�}�p���5�����e���]���c���((,�e��f���-��:}��puc��.y��0�m����f0�����^~�btc90wt��#�j���<8[��qpq����`�����\ ���wt�u��\#�1��y�)h�)��*�po�������xe�\�o9�#�����_?)�)��z���?y��~>�������6�7���v9�_� %7�c�3x������k��p��a]������p���2c��w�j�et���6�"�vb���5����m�?? )8��li�����;��{�f�x�>������[����g#/�g��0��[s�77:�xeq(�2����{ ra�e���49����f���0���� �|7�����c��x��� 4�>��$���0r�p����ex��3���'��-^a�1c\��c{vx|9����au��`d�m�dy��ie��������������u��z�/)��5�.��m;�v��~ ��>j[r��=xx�.�j�m/&��x��*�������j��u������ &`��=~�x���tm4x-���og�_��~m�#���7?��f t�>7 �+3�0��s�0k(4�w�]md�4t��yr�a��b�*v`��0e��r�i��)���$p� ��[{�������.���hv��_�\$2�r��p����gf�|f��ma�g��������������g�c� �!�^���<7�k�����'s[y���j���c��wfjy0��� ���w��@>��i�s�&�r�i: �����w���n���sz���a��2uh����[da���d��d0�_�f~%�����-�=�~b�+�q��xz�+zjct��k������l��in�6��o#�u�i�-�qg���+o9���d�2�*�lj"!?5�f�*��}f��` t_b������=kw5�c.x��.�*���)��n/�c��\l�������w�-���u������������u��lt��6?9��yan|*������r������0��rm��_�v"s���tvgk�����k�������q|�8p����[email protected];��l-�0�x�ul�����d�c`&�/~�o6*z�l�7�����q�[��k����a�p&]��)������*�o]�����n��+a���)���k]kt�j���fd`)+�.�� ;��`,3�x�9�>���4��!����1n����ne�s�*1x$� �kf� z�i��f����*�1s����r��j'9u������ �����e�������e����m��g��9a��63�o�p�r�s�/��pv���z�d������z��%��#�xj�;�h�j��m����.m�u�������� 3����r�8)\rr����l ����� ����=���6e����:�%m�j�rp(?����a�=��':����_�2f��o����!s�����u����'.�d_��!���q��^ �b������2n�����)b:��h���"�c�~o� 7��tv'��w$f`�;�=�4yc������2�g���z�8����m����^]"��s���y=���9��r��[���i��ux���|�i���� 4!u�/.��@���������jp:�m���m�r��h�� �o��kz���]�_� �p�!��$����6c����8������k��|uo������k�*:��������8�l����)�`�iw���z�����b�5��e�?���5�x�'�+��,��ici��%���3�����i��+a�)�{�vi��8��u�h7'l�/�����a�{k5�� ���f9s���9����-�"?���rt=z�p�?y6�r%��e���u�����w�d,��r!�'��)��>v�����:����uh����-��/��i�_�����>(yr��w��� b�f��������mk��oi�b�e`,[�n&��e��us�����2���4�g�"xh�,�*d5}3��������w��jj�z��u]������)���u������zp����lk�\o`����?��m��f�d{��}k�o���gi����^�x�m� �w����j��.[=����te0(�9e�wz�������w1�x�)��ta+�u�ei�+�:�@�y�[dg&��j�f���x�� c�3�t�� ���;�q`� ��a�����/���uj%w�th���l������� ��t��w��,�����/k�� cia.gov

  • ed zimney, md is a board-certified physician with more than 30 years of experience. after medical school, residency, and a fellowship, dr. zimney then worked at wyeth, ici (now astrazeneca), immunex, and amgen in the areas of drug advertising review, drug safety surveillance, medical information, and marketing. he also worked at the u.s. food and drug administration (fda) for three years in the division of drug marketing, advertising, and communications (ddmac) as a medical officer and as a branch chief, regulating prescription drug advertising at a national level. he received his medical degree...read more everydayhealth.com

  • in july 2006, the government of iraq and the un began work to formulate the international compact with iraq (ici), a five-year framework for iraq to achieve economic self-sufficiency within its region and the world. on may 3, 2007 in sharm el-sheikh the ici was formally launched by more than 70 countries and international organizations, many represented at the ministerial level. factmonster.com

  • data collection methods: several forms are used to collect data: direct face-to-face interviews, interactive computer interviewing (ici), medical record abstraction, physical examination, and laboratory examination. cases and controls are seen every three months, with data collected at each visit using all the data collection instruments except the ici. the ici is conducted every six months. clinical investigators recruit study subjects at their clinical sites. study coordinators are usually research nurses who have been centrally trained on both interviewing technique, as well as the intent of the questions. clinicians and study coordinators are trained in protocol procedures, sample collection and processing, oral and skin examinations, and skinfold measurements. hhs.gov

  • in july 2006, the government of iraq and the un began work to formulate the international compact with iraq (ici), a five-year framework for iraq to achieve economic self-sufficiency within its region and the world. on may 3, 2007 in sharm el-sheikh the ici was formally launched by more than 70 countries and international organizations, many represented at the ministerial level. infoplease.com

  • as a summer law clerk in pia, i had the fortunate opportunity to experience ici both as a part of the production team and as a member of the audience. it was exciting to be a part of such an event and to meet so many copyright officials from around the world. loc.gov

  • menendez ja, colomer r, lupu r. omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ici 182,780 (faslodex) efficacy in human breast cancer cells. int j cancer 2004;10;109:949-54. view abstract. medicinenet.com

  • immune checkpoint inhibitors (ici) improve survival for adults with metastatic nsclc. despite limited data on ici efficacy in adults with poor performance status (ps), oncologists often elect to treat this population with ici given their relatively favorable toxicity profile and potential for durable response. we aimed to describe the timing of ici and patients' survival based on ps, and explore the effect of late ici use on end-of-life (eol) care. medpagetoday.com

  • the prisma statement was followed in the systematic review and meta-analysis (36). systematic literature search was conducted on pubmed, embase, web of science and cochrane library up to june 16, 2019. two investigators (wu and xu) searched the databases independently. the search term was as follows: (pd-1 or pd-l1 or ctla-4 or ipilimumab or tremelimumab or nivolumab or pembrolizumab or lambrolizumab or atezolizumab or avelumab or durvalumab or “immune checkpoint inhibitor” or “immune checkpoint inhibitors” or “ici” or “icis” or “immune checkpoint blocker” or “immune checkpoint blockers” or “icb” or “icbs”) and (mutation burden or mutational burden or mutation load or mutational load or tmb or tml). when duplicate reports were identified, the one with larger sample size and more detailed information was selected. we also reviewed references in articles finally included to identify studies potentially missed. nih.gov