naat Definitions


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  • nucleic acid amplification test, or naat, is a generic term referring to all molecular tests used to detect viral genomic material. naat assays are the preferred method of diagnosis because they can provide confirmed evidence of infection. despite the specificity of molecular testing, false positive naat results have been reported in rare cases and may depend on the type of naat assay performed and patient population (i.e., limited or no prevalence of viral transmission) being tested. this problem can be exacerbated when zika virus testing is performed on patient populations not recommended in the zika testing algorithms. cdc.gov

  • nucleic acid amplification tests (naat) – naat performed on whole blood is relatively sensitive for the diagnosis of hme in the acute disease stage prior to doxycycline treatment. however, there are no assays or point-of-care testing for hme that are cleared or approved by the u.s. food and drug administration (fda). hhs.gov

  • compare patient-collected saliva and health care worker collected nasopharyngeal and nasal mid-turbinate swabs for severe acute respiratory syndrome coronavirus 2 (sars-cov-2) detection by nucleic acid amplification testing (naat). all tests will be performed using previously-validated, eua naats that are available in the clinical microbiology laboratory, including the mayo clinic laboratory developed test (ldt). mayoclinic.org

  • but the authors argued that these are resource-intensive procedures, and added that nucleic-acid amplification testing (naat) may have the potential to "substantially decrease the duration of isolation and hospital costs required to evaluate inpatients for active tb." a "novel approach" would be "[naat] testing to guide discontinuation of respiratory isolation," they said. medpagetoday.com

  • ideally, biopsied samples of other tissue should be cultured fresh, but naat can be used for fixed tissues (eg, for biopsied lymph node if histologic examination unexpectedly detects granulomatous changes). the latter use of naat has not been approved but can be extremely useful, although positive and negative predictive values have not been established. merckmanuals.com

  • the potential benefits of rapid naat are perhaps best exemplified by clinical studies of hsv encephalitis in adults and enterovirus meningitis in children. pcr testing on csf is as sensitive as brain biopsy for the diagnosis of hsv encephalitis [14]. timely access to enterovirus reverse transcription pcr (rt-pcr) results facilitates shorter hospital stays, reduces antibiotic use, and lessens ancillary laboratory testing [15]. nih.gov