xanomeline Definitions


a muscarinic acetylcholine receptor agonist with reasonable selectivity for the m1 and m4 subtypes, possibly useful in treating alzheimer's disease and schizophrenia.

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  • and in a surprising move, karuna therapeutics is resurrecting an eli lilly drug originally designed to be a part of a combination therapy to treat schizophrenia and alzheimer's that was shelved in the 1990s because of the severity of its side effects. the new "karxt" formulation, xanomeline, is a muscarinic m1/m4 agonist combined with the anticholinergic drug trospium to reduce its side effect profile. medpagetoday.com