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xenotransplantation Definitions

noun

the transplantation of biological or organic matter from a given species into a different one, especially when this matter has been altered (such as by genetic engineering)

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  • their birth marks the first step in making genetically modified pigs whose organs and cells can be successfully transplanted into humans without being rejected by the human immune system. the process of xenotransplantation (the transfer of organs from one species to another) may one day solve the worldwide organ shortage problem. factmonster.com

  • the office of science policy guides and coordinates the development of science policy in areas such as genetic testing, environmental health, xenotransplantation and asthma. the office works closely with all of the agencies and institutes within the department and with external scientific and research communities. the office of science policy is in the office of the assistant secretary for planning and evaluation in the department of health and human services. hhs.gov

  • their birth marks the first step in making genetically modified pigs whose organs and cells can be successfully transplanted into humans without being rejected by the human immune system. the process of xenotransplantation (the transfer of organs from one species to another) may one day solve the worldwide organ shortage problem. infoplease.com

  • researchers also are studying the possibility of living-organ transplant from one species to another (xenotransplantation). xenotransplantation research includes genetic engineering of pigs so that their organs are compatible for transplant to humans. in addition, researchers are looking at treating diseases through transferring genes into tissues (gene therapy). for example, gene therapy may treat rejection of a heart transplant. mayoclinic.org

  • "until we learn to grow organs via tissue engineering, which is unlikely in the near future, xenotransplantation seems to be a valid approach to supplement human organ availability. despite many setbacks over the years, recent genetic and immunologic advancements have helped revitalized progress in the xenotransplantation field," lead investigator dr. muhammad mohiuddin, of the cardiothoracic surgery research program at the u.s. national heart, lung, and blood institute, said in the news release. medicinenet.com

  • finally, they saw that in a xenotransplantation murine model of human cml, mice treated for 4 weeks with the combination of imatinib and tigecycline had both a greater reduction in cml burden compared with mice treated with vehicle or either drug alone, and a 95% reduction in more primitive lscs. combination therapy also was associated with a low burden of lscs compared with imatinib alone, suggesting that the combined agents could help prevent relapse. medpagetoday.com