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xmrv Definitions

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xenotropic murine leukemia virus, a laboratory-created virus thought capable of infecting humans, now believed to be a contaminant.

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  • the possibility of a link between a virus called xmrv and chronic fatigue syndrome may have patients seeking a type of treatment called antiretroviral therapy. xmrv is classified as a retrovirus, which means infection with it may allow other, previously dormant (inactive) viruses within the body to reactivate. the human immunodeficiency virus (hiv) is the best-known retrovirus, and the antiretroviral drugs on the market are aimed at treatment of hiv, not xmrv. everydayhealth.com

  • there is no known single cause of cfs. some authorities believe it is a condition shared by many different underlying diseases rather than an entity unto itself; others believe it is caused by a defect of the immune system. hormonal deficits, low blood pressure, and viral infections have been studied as possible causes or contributors. the postulated causal link with epstein-barr virus hypothesized in the mid-1980s has been discounted. in 2009 researchers announced that they had found xenotropic murine-leukemia-virus-related virus (xmrv) in many patients with cfs, but the study did not show that xmrv was linked to cfs. other studies failed to replicate its findings, and the paper was later retracted. factmonster.com

  • there is no known single cause of cfs. some authorities believe it is a condition shared by many different underlying diseases rather than an entity unto itself; others believe it is caused by a defect of the immune system. hormonal deficits, low blood pressure, and viral infections have been studied as possible causes or contributors. the postulated causal link with epstein-barr virus hypothesized in the mid-1980s has been discounted. in 2009 researchers announced that they had found xenotropic murine-leukemia-virus-related virus (xmrv) in many patients with cfs, but the study did not show that xmrv was linked to cfs. other studies failed to replicate its findings, and the paper was later retracted. infoplease.com

  • in this study, researchers from the university of utah and emory university/veterans affair medical center tested how effectively 45 compounds used to treat hiv and other viral infections worked against xmrv. raltegravir was the most effective, and three other drugs -- l-00870812, zidovudine (zdv or azt), and tenofovir disoproxil fumarate (tdf) -- also prevented xmrv replication. medicinenet.com

  • xmrv had first been isolated from human prostate cancer cells in 2006. consequently, coffin, pathak, and colleagues examined two prostate cancer cell lines that produce xmrv "virtually identical to the viruses recently found in patient samples," as well as the progenitor human prostate tumor xenograft, called cwr22, that had been passaged in mice. medpagetoday.com