zafirlukast Definitions


an oral leukotriene receptor antagonist for the maintenance treatment of asthma.

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  • the controllers start with mild medicines that are almost historic these days like cromolyn sodium [intal] and nedocromil [tilade], which are not used as often as in the past. then there are leukotriene modifiers such as singulair [montelukast] zafirlukast [accolate], zileuton [leutrol, zyflo], and what they do is block mediators from causing cells to either produce mucous or go into spasm. they are a preventative therapy or controller. everydayhealth.com

  • los modificadores de leucotrienos se pueden utilizar como una alternativa a los corticoesteroides para el asma leve o se pueden agregar a un plan de tratamiento cuando un tratamiento con corticoesteroides inhalados por sí solo no da como resultado un tratamiento estable del asma. estos incluyen montelukast (singulair), zafirlukast (accolate) y zileuton (zyflo, zyflo cr). mayoclinic.org

  • in clinical trials, an increased proportion of zafirlukast patients over the age of 55 years reported infections as compared to placebo-treated patients. a similar finding was not observed in other age groups studied. these infections were mostly mild or moderate in intensity and predominantly affected the respiratory tract. infections occurred equally in both sexes, were dose-proportional to total milligrams of zafirlukast exposure, and were associated with coadministration of inhaled corticosteroids. the clinical significance of this finding is unknown. medicinenet.com

  • zafirlukast comes as a tablet to take by mouth. it is usually taken two times a day, 1 hour before or 2 hours after meals. try to take zafirlukast at around the same times every day. follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. take zafirlukast exactly as directed. do not take more or less of it or take it more often than prescribed by your doctor. medlineplus.gov

  • leukotriene modifiers, such as montelukast, zafirlukast, and zileuton, also help control asthma. they are anti-inflammatory drugs that prevent the action or synthesis of leukotrienes. leukotrienes are chemicals made by the body that cause bronchoconstriction. these drugs, which are taken by mouth, are used more to prevent asthma attacks than to treat them. merckmanuals.com