zalcitabine Definitions


the compound 2'-3'-dideoxycytidine, a nucleoside analog reverse transcriptase inhibitor, formerly used in antiretroviral therapy

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  • people being treated for hivĀ or aids may develop neuropathy from effects of the virus and the drugs used to treat it. common symptoms include burning, stiffness, prickling, tingling, and loss of feeling in the feet and hands. the drugs videx (didanosine), hivid (zalcitabine), and zerit (stavudine) are most frequently associated with neuropathic symptoms. (10) everydayhealth.com

  • lamivudine: in vitro studies in peripheral blood mononuclear cells, u937 and molt-4 cells revealed that lamivudine significantly inhibited zalcitabine phosphorylation in a dose dependent manner. effects were already seen with doses corresponding to relevant plasma levels in humans, and the intracellular phosphorylation of zalcitabine to its three metabolites (including the active zalcitabine triphosphate metabolite) was significantly inhibited. medicinenet.com