zanamivir Definitions


a neuraminidase inhibitor used in the treatment and prophylaxis of influenzavirus.

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  • * six influenza viruses showed reduced or highly reduced inhibition by at least one neuraminidase inhibitor. four a(h1n1)pdm09 viruses showed highly reduced inhibition to oseltamivir and peramivir while showing normal inhibition to zanamivir. in addition, one b/victoria virus showed highly reduced inhibition to peramivir and reduced inhibition to oseltamivir and zanamivir, while another influenza b/victoria virus showed reduced inhibition to zanamivir. cdc.gov

  • some people using zanamivir (especially children) have had sudden unusual changes in mood or behavior. it is not certain that zanamivir is the exact cause of these symptoms. even without using zanamivir, anyone with influenza can have neurologic or behavioral symptoms. call your doctor right away if the person using this medicine has: everydayhealth.com

  • vaccination is recommended for persons who are likely to be exposed to influenza (such as health-care workers) or who are at risk for complicatons. the antiviral drugs amantadine and rimantadine are effective against most strains of type a influenza, and zanamivir and oseltamivir against types a and b. given within two days of the first appearance of symptoms, they may reduce the symptoms; they may also be given to prevent influenza infection in persons exposed to the disease. uncomplicated influenza requires only rest and treatment of symptoms, and the use of antibiotics has greatly reduced fatalities from secondary infections. return to normal activity should be undertaken slowly, as relapses are easily precipitated. factmonster.com

  • lewin completed two stages of research and analysis culminating in this report.  the first was an environmental scan of the current application of economic evidence in decision-making for new health technologies.  the second consisted of four case studies conducted to illustrate the use of this evidence for four technologies:  nucleic acid testing; relenza (zanamivir); drug-eluting stents; and implantable cardioverter-defibrillators. hhs.gov

  • two drugs (in the neuraminidase inhibitors class), oseltamivir (commercially known as tamiflu) and zanamivir (commercially known as relenza) can reduce the severity and duration of illness caused by seasonal influenza. the efficacy of the neuraminidase inhibitors depends on their administration within 48 hours after symptom onset. for cases of human infection with h5n1, the drugs may improve prospects of survival, if administered early, but clinical data are limited. the h5n1 virus is expected to be susceptible to the neuraminidase inhibitors. infoplease.com

  • patients with respiratory diseases may experience breathing problems when treated with zanamivir due to irritation of the breathing tubes by the particles from the inhaler. if breathing problems occur, zanamivir should be discontinued. patients who have asthma or other breathing problems that make them sensitive to inhaled particles should have a fast acting, inhaled bronchodilator available to treat any breathing problem that may occur when zanamivir is used. medicinenet.com

  • el zanamivir viene con un inhalador de plástico llamado diskhaler (dispositivo para inhalar el polvo) y cinco rotadisks (paquetes circulares de papel metálico que contienen cuatro ampollas (blísteres) del medicamento). polvo zanamivir sólo pueden ser inhaladas con el diskhaler. no quite el polvo de los envases, mezclar con cualquier líquido, o se inhale con cualquier otro dispositivo de inhalación. no perfore ni abra ninguna ampolla de medicamento sino hasta que vaya a inhalar una dosis con el diskhaler. lea detenidamente las instrucciones del fabricante, en las cuales se explica cómo preparar e inhalar una dosis de zanamivir usando el diskhaler. no olvide preguntarles a su farmacéutico o a su médico si tiene alguna duda sobre cómo preparar o inhalar este medicamento. medlineplus.gov

  • the good news is that the neuraminidase inhibitors oseltamivir (tamiflu) and zanamivir (relenza) are likely to be active against the majority of this year's circulating strains. oseltamivir is the drug of choice for treating children with influenza. zanamivir is typically inhaled using a "diskhaler" device, which is difficult for children to coordinate. because of this, it is not recommended for treatment in children less than 7 years of age (for prophylaxis, it is 5 years of age) and is contraindicated in children with respiratory disease, including asthma. an intravenous form of zanamivir exists. while it is not yet approved by the fda, it can be considered in patients who are critically ill. medpagetoday.com

  • el zanamivir se administra por vía inhalatoria, en dosis de 2 pulverizaciones (10 mg) 2 veces al día, y puede indicarse en adultos y niños ≥ 7 años. en ocasiones, el zanamivir causa broncoespasmo y no debe administrarse a pacientes con enfermedad reactiva de la vía aérea. no obstante, algunos pacientes no pueden utilizar un dispositivo de inhalación. merckmanuals.com