zebularine Definitions


an inhibitor of dna methylation that is used as an anticancer drug

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  • zebularine is a dna demethylating agent that can induce the expression of two specific immunosuppressive enzymes, indolamine-2,3-deoxygenase-1 and kynureninase. to see if this action could be exploited therapeutically, leif g. salford, md, phd, and colleagues induced diabetes in a group of rats through injections of streptozotocin, and then grafted islets of langerhans into the subcapsular space of the kidney. half of the animals were then treated with zebularine for 14 days and the other received no treatment. medpagetoday.com