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zidovudine Definitions

noun

a nucleoside analog reverse transcriptase inhibitor, a type of antiretroviral drug, the first approved treatment for hiv.

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aztazidothymidinezdv

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  • in 1981, the first known case of aids (autoimmune deficiency syndrome) — the final stage of an hiv (human immunodeficiency virus) infection — was reported. (1) six years later, in 1987, the food and drug administration (fda) approved the first drug for the treatment of aids: zidovudine or azidothymidine (azt). (2) everydayhealth.com

  • the search for cures and palliatives for aids has yielded drugs such as zidovudine (azt), which inhibits the transcription of rna to dna in human immunodeficiency virus (hiv). ganciclovir and cidofovir are used in the treatment of cytomegalovirus (cmv), a virus that affects the eyes of immunosuppressed patients. fomivirsen, which is an antisense drug, is also used to treat cmv. factmonster.com

  • protease inhibitors, available since late 1995, seem an even more promising, though costly, class of antiretroviral drugs. protease inhibitors are prescribed in combination with older antiretroviral medications like zidovudine (azt). cost estimates for protease inhibitors alone range from $6,000 to $14,000 a year (gilden 1996; aids treatment data network 1996; tenncare news 1996; and bartlett and moore 1996). combination therapies, including one of the three currently available protease inhibitors, can cost up to $18,000 a year (american public health association 1996). as noted, additional medications often are needed to prevent or suppress aids-related infections and conditions. thus, the already high cost of pharmaceutical treatment for aids has recently grown substantially. hhs.gov

  • the search for cures and palliatives for aids has yielded drugs such as zidovudine (azt), which inhibits the transcription of rna to dna in human immunodeficiency virus (hiv). ganciclovir and cidofovir are used in the treatment of cytomegalovirus (cmv), a virus that affects the eyes of immunosuppressed patients. fomivirsen, which is an antisense drug, is also used to treat cmv. infoplease.com

  • zidovudine (formerly called azidothymidine [azt]), a pyrimidine nucleoside analogue active against hiv. retrovir iv infusion is a sterile solutionfor intravenous infusion only. each ml contains 10 mg zidovudine in water for injection. hydrochloric acid and/or sodium hydroxide may have been added to adjust the ph to approximately 5.5. retrovir iv infusion contains no preservatives. the chemical name of zidovudine is 3′-azido-3′-deoxythymidine. medicinenet.com

  • zidovudine controls hiv infection but does not cure it. continue to take zidovudine even if you feel well. do not stop taking zidovudine without talking to your doctor. when your supply of zidovudine starts to run low, get more from your doctor or pharmacist. if you miss doses or stop taking zidovudine, your condition may become more difficult to treat. medlineplus.gov

  • the promote (pregnant women and infants trial) enrolled hiv-infected antiretroviral-naïve pregnant women of 12-28 weeks' gestation. the women were stratified by gravidity and gestational age. they were assigned to either efavirenz plus zidovudine and lamivudine or to lopinavir boosted with ritonavir and the same nucleoside reverse transcriptase inhibitors. the infants received zidovudine or nevirapine. women were counseled to breastfeed for 1 year after delivery. medpagetoday.com

  • melanocyte activation may be a normal physiologic variant in people with darker skin. this variant, often called ethnic melanonychia, requires no treatment. other causes of melanocyte activation include trauma, pregnancy, addison disease and other endocrine disorders, infections, postinflammatory hyperpigmentation, and the use of certain drugs, including doxorubicin, 5-fluorouracil, zidovudine, and psoralens. merckmanuals.com