an asthma drug that blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway.
the controllers start with mild medicines that are almost historic these days like cromolyn sodium [intal] and nedocromil [tilade], which are not used as often as in the past. then there are leukotriene modifiers such as singulair [montelukast] zafirlukast [accolate], zileuton [leutrol, zyflo], and what they do is block mediators from causing cells to either produce mucous or go into spasm. they are a preventative therapy or controller. everydayhealth.com
los modificadores de leucotrienos se pueden utilizar como una alternativa a los corticoesteroides para el asma leve o se pueden agregar a un plan de tratamiento cuando un tratamiento con corticoesteroides inhalados por sí solo no da como resultado un tratamiento estable del asma. estos incluyen montelukast (singulair), zafirlukast (accolate) y zileuton (zyflo, zyflo cr). mayoclinic.org
the leukotriene modifier medications are also used in children. montelukast is available in granules that can be sprinkled on food and is approved for infants as young as 6 months of age. it is also available in chewable form. zafirlukast is available for children 5 years old and up. zileuton is recommended for children 12 years old and up. medicinenet.com
zileuton is used to prevent wheezing, shortness of breath, coughing, and chest tightness due to asthma. zileuton is not used to treat an asthma attack (sudden episode of shortness of breath, wheezing, and coughing) that has already started. zileuton belongs to a class of medications called leukotriene synthesis inhibitors. it works by stopping the formation of certain natural substances that cause swelling, tightening, and mucus production in the airways. medlineplus.gov
leukotriene modifiers, such as montelukast, zafirlukast, and zileuton, also help control asthma. they are anti-inflammatory drugs that prevent the action or synthesis of leukotrienes. leukotrienes are chemicals made by the body that cause bronchoconstriction. these drugs, which are taken by mouth, are used more to prevent asthma attacks than to treat them. merckmanuals.com