an antipsychotic drug used in the treatment of schizophrenia etc.
while you are taking ziprasidone, you may be more sensitive to extreme temperatures, such as very hot or cold conditions. avoid getting too cold, or becoming overheated or dehydrated. drink plenty of fluids, especially in hot weather and during exercise. it is easier to become dangerously overheated and dehydrated while you are taking ziprasidone. everydayhealth.com
since the end of the primary research phase of this product, pharmacia & upjohn has launched reboxetine (vestra®) as a new therapy for depression. this drug is the first in what is likely to be a new class of antidepressants that work almost exclusively on the norepinephrine system. pfizer is expected to re-submit a new drug application for a new atypical antipsychotic, ziprasidone (zeldox®) in 2000, even though this product was received a non-approvable letter from fda in 1999. hhs.gov
carbamazepine (tegretol) increases the body's ability to eliminate ziprasidone and, therefore, may reduce the levels and lessen the effectiveness of ziprasidone. conversely, ketoconazole (nizoral) reduces the body's ability to eliminate ziprasidone and may cause increases in levels of ziprasidone and more side effects. ketoconazole does this by blocking the enzyme that eliminates ziprasidone, cytochrome p450 3a4. other drugs that also block this enzyme and may increase the levels of ziprasidone include itraconazole (sporanox), fluconazole (diflucan), erythromycin, clarithromycin (biaxin), nefazodone (serzone), verapamil (calan, isoptin, verelan), and diltiazem (cardizem, tiazac, dilacor). medicinenet.com
ziprasidone comes as a capsule to take by mouth. it is usually taken twice a day with food. take ziprasidone at around the same times every day. follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. take ziprasidone exactly as directed. do not take more or less of it or take it more often than prescribed by your doctor. medlineplus.gov
a new label warning will advise physicians and patients that six cases of "drug reaction with eosinophilia and systemic symptoms," or dress, have been seen worldwide with ziprasidone. although none of those cases were fatal, dress has led to death with other agents; the fda said mortality rates can range up to 10%. medpagetoday.com
long-term side effects of antipsychotics may include weight gain and the metabolic syndrome. metabolic syndrome is excess fat in the abdomen with reduced sensitivity to insulin’s effects ( insulin resistance), a high blood sugar level, abnormal cholesterol levels, and high blood pressure. the risk of this syndrome may be lower with aripiprazole and ziprasidone. merckmanuals.com