zoledronic Definitions


of or pertaining to zoledronic acid or its derivatives

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  • however, patients who received zoledronic acid had a significantly lower incidence of bone lesions and high calcium levels at the time that their disease progressed. a few patients developed fever with their zoledronic acid treatments and one developed necrosis of the jaw bone (localized bone deterioration or bone death), but overall the zoledronic acid was felt to be well-tolerated. everydayhealth.com

  • zoledronic acid belongs to a class of drugs known as bisphosphonates, which help delay bone complications such as fractures, spinal cord compression and bone pain. but zoledronic acid has been linked with kidney toxicity and other reactions. denosumab, a newer drug called a monoclonal antibody, is superior to zoledronic acid in reducing skeletal problems and better tolerated, the study found. medicinenet.com

  • you may experience a reaction during the first few days after you receive a dose of zoledronic acid injection. symptoms of this reaction may include flu-like symptoms, fever, headache, chills, and bone, joint or muscle pain. these symptoms may begin during the first 3 days after you receive a dose of zoledronic acid injection and may last 3 to 14 days. your doctor may tell you to take a nonprescription pain reliever/fever reducer after you receive zoledronic acid injection to prevent or treat these symptoms. medlineplus.gov

  • "early zoledronic acid treatment has been found to fully preserve ovariectomy (ovx)-induced deterioration of bone micro-architecture and strength over time. however, there are no in vivo data concerning the effects of zoledronic acid treatment on marrow adiposity," the researchers wrote. "because both osteoblasts and adipocytes are of mesenchymal origin, we hypothesized that zoledronic acid treatment might negatively impact marrow adipogenesis." medpagetoday.com

  • bisphosphonates (alendronate, risedronate, ibandronate, and zoledronic acid) are useful in preventing and treating all types of osteoporosis and are usually the first drugs used. bisphosphonates have been shown to reduce bone turnover and thus reduce bone loss as well as reduce the risk of fractures. alendronate and risedronate can be taken by mouth (orally). zoledronic acid can be given by vein (intravenously). ibandronate can be taken orally or intravenously. merckmanuals.com