a sulfonamide anticonvulsant drug.
zonisamide is not fda-approved as a migraine preventive, but it can be used for this purpose. the effective dose for migraine prevention is 25-300 mg per day. i have not found zonisamide to be useful to prevent migraines, except on rare occasion. you could try another preventive medication, such as a beta-blocker, calcium channel blocker, tricyclic anti-depressant or depakote (divalproex). if that turns out to be effective, i would try to taper off of zonisamide and/or topamax. everydayhealth.com
between 2006 and 2011 the study team randomly assigned more than 200 obese men and women to one of three groups. one group took 200 milligrams of zonisamide daily, another got 400 mg of zonisamide daily and one received a dummy pill. the participants' average age was 43, and their average body-mass index (bmi) was nearly 38. bmi is a calculation of body fat based on height and weight, and a bmi of more than 30 is considered obese. none had diabetes. medicinenet.com
zonisamide may help control your condition but will not cure it. it may take 2 weeks or longer before you feel the full benefit of zonisamide. continue to take zonisamide even if you feel well. do not stop taking zonisamide without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. if you suddenly stop taking zonisamide, your seizures may become worse. your doctor will probably decrease your dose gradually. medlineplus.gov
in both adult and pediatric patients, investigators found significant increases in serum levels of topiramate, rufinamide, and n-desmethylclobazam (a clobazam metabolite) as cannabidiol doses increased (all p<0.01). they also saw significant increases in serum zonisamide (p=0.02) and eslicarbazepine (p=0.04) in adult patients only. no pediatric patients in the study took eslicarbazepine. medpagetoday.com
the different adverse effects of antiseizure drugs may influence the choice of drug for an individual patient. for example, antiseizure drugs that cause weight gain (eg, valproate) may not be the best option for an overweight patient, and topiramate or zonisamide may not be suitable for patients with history of kidney stones. merckmanuals.com