zwitterionic Definitions


of or pertaining to a zwitterion.

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  • taken together, the present smfret, anisotropy, and quenching data and our previous protein-stability experiments13 unveil contrasting behaviors of mistic in nonionic vs. zwitterionic micelles: whereas polar headgroup contacts in small zwitterionic micelles induce a compact fold that is thermodynamically stable in spite of poor shielding from the aqueous solvent, mistic readily sacrifices tight intramolecular packing for the benefit of deeper hydrophobic burial accompanied by greater stability as the size of nonionic micelles is increased. thus, although intramolecular interactions enabled by protein compaction and the release of hydration water molecules upon hydrophobic burial generally make important contributions to protein stability,4,5 neither of these factors governs the thermodynamic stability of mistic. nih.gov